ジャック・ジャンク・ジャンキー

Set in Skid Row, USA. The case takes place at Jack Junk, a jack-of-all-trades shop! May is the physical type and Louise is the brain type. They seem to be opposites, but they are the best of buddies. They solve a search for a brother, fight off a stalker, and solve a mysterious drug epidemic! (source: Asuka, translated)